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IGNOU MST-019 Solved Assignment 2024 | MSCAST | IGNOU
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IGNOU MST-019 Assignment Question Paper 2024
mst-019-solved-assignment-2024-qp-8e24e610-06c9-4b43-84f6-a5bf6ef5ab5c
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(a) In the natural history of a disease define: total preclinical phase, detectable pre-clinical phase and clinical phase. Suppose on 10 am on 25.01.2010 a disease A onset you biologically. Suppose test of the disease A can detect it exactly after completion of 1000 days of biologically onset. Suppose signs and symptoms develop exactly after completion of 1010 days of biologically onset. Suppose you consult doctor exactly after 1015 days of biologically onset of the disease. Suppose outcome the treatment is cure. What is duration of (i) total preclinical phase (ii) detectable pre-clinical phase (iii) clinical phase.
(b) Ifp \mathrm{p} denotes proportion andq \mathrm{q} denotes odds then prove thatq=(p)/(1-p) \mathrm{q}=\frac{\mathrm{p}}{1-\mathrm{p}} . Find the range ofq \mathrm{q} . If the odds of smokers in a study are 0.25 then find the proportion of smokers in the study. Assume that each subject of the study is either a smoker or non-smoker.
(c) A trial is conducted in which some people with diseaseX \mathrm{X} were randomly allocated into two groups. First group was advised to do some morning walk for 30 minutes and take light food each day and second group was given one injection and one100mg 100 \mathrm{mg} tablet once a day to control disease X. The injection can cause loose motion in some cases and100mg 100 \mathrm{mg} tablet has no side effect. At the end of two months,90% 90 \% of group I and80% 80 \% of group II had recovered from diseaseX \mathrm{X} .
i) What are the regimens for group I and group II in this trial?
ii) What are the efficacies in group I and group II?
iii) What are the safety issues in group I and group II in this trial? -
(a) What is the basic difference between (a) cross-sectional (b) cohort and (c) case control study designs. Explain with suitable examples of each design.
(b) RTPCR test is applied on 300 covid patients and 200 non-covid patients. The results of the test are shown as follows.
Disease status | Total | |||||
Yes |
No |
|||||
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480 | 40 | 520 | |||
120 | 360 | 480 | ||||
Total | 600 | 400 | 1000 |
- (a) In usual notations you are given the following information
(b) If you are told that haemoglobin
MST-019 Sample Solution 2024
mst-019-solved-assignment-2024-ss-8e24e610-06c9-4b43-84f6-a5bf6ef5ab5c
- (a) In the natural history of a disease define: total preclinical phase, detectable pre-clinical phase and clinical phase. Suppose on 10 am on 25.01.2010 a disease A onset you biologically. Suppose test of the disease A can detect it exactly after completion of 1000 days of biologically onset. Suppose signs and symptoms develop exactly after completion of 1010 days of biologically onset. Suppose you consult doctor exactly after 1015 days of biologically onset of the disease. Suppose outcome the treatment is cure. What is duration of (i) total preclinical phase (ii) detectable pre-clinical phase (iii) clinical phase.
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Total Preclinical Phase: This is the period between the biological onset of the disease and the appearance of signs and symptoms. It is the time during which the disease is present in the body, but not yet clinically apparent.
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Detectable Pre-Clinical Phase: This is the part of the preclinical phase during which the disease is biologically present and can be detected by tests, but signs and symptoms have not yet appeared. It is the time between when the disease becomes detectable and when it becomes clinically apparent.
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Clinical Phase: This is the period after the signs and symptoms of the disease have appeared. It ends when the disease is either cured or results in the patient’s death.
- Biological onset of disease A: 10 am, 25.01.2010
- Test can detect disease A: After 1000 days of biological onset
- Signs and symptoms appear: After 1010 days of biological onset
- Consultation with doctor: After 1015 days of biological onset
- Outcome of treatment: Cure
- Total Preclinical Phase: From biological onset to the appearance of signs and symptoms = 1010 days
- Detectable Pre-Clinical Phase: From when the test can detect the disease to the appearance of signs and symptoms = 1010 days – 1000 days = 10 days
- Clinical Phase: From the appearance of signs and symptoms to consultation with the doctor (since the outcome is cure, we consider the clinical phase to end at consultation) = 1015 days – 1010 days = 5 days
(i) Total Preclinical Phase: 1010 days
(ii) Detectable Pre-Clinical Phase: 10 days
(iii) Clinical Phase: 5 days
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